In an effort to minimise the amount of equipment in my 100L cube, I replaced my CO2 diffusor with a Sera 500 CO2 reactor. I added this in the outlet pipework of my Eheim filter which is rated at around 450L/hour. I found that the rotors in the reactor slowed down and stopped almost immediately which resulted in a big build up of gas in the reactor and poor CO2 dissolved in the tank. I took the unit apart and found two issues. Firstly it's possible to push the plastic pipe that the rotors run on too tightly into the lid of the reactor which causes friction. Secondly and more disappointingly, both the rotors had very rough areas from the moulds on their inside surfaces which added a great deal of friction and resistance. The plastic pipe also had a moulding line on both sides. Five minutes with the Dremel, finished off with fine sandpaper and both rotors run fine. I'd bought the Sera unit instead of some of the cheaper copies in the hope of better build quality!